About RAM, I'm only worried about bandwidth. On my V1 I had so many framedrops on zelda totk, it was something constant throughout the game.
Overclocking the RAM is enough to fix the issue almost 100%. I was really surprised, because I thought the CPU was the culprit.
So, imagining a scenario where you have a GPU 6x bigger with a 4x increase on bandwidth, that's what makes me worried. We would also have 7 CPU cores for games (probably), but I don't know what impact it could have on BW.
But I'm not a developer; I have no background on this to understand it in details. I just remember (years ago) reading that the switch was fine with the BW it has, because the GPU was "weak", but what I saw on zelda totk had me thinking more about it. I just hope I won't see people OC'ing RAM on a hacked switch 2 and having a much, much better performance of it.