Spoiler What do you want to see in Metroid 6?

[Buried In Time]

Metroid Primal - The Space Pirates are back with a brand new rogues' gallery for Samus to hunt down. She tracks them to a technologically primitive planet teeming with deadly wildlife but gets shot down. Her ship and power suit are damaged beyond repair and she doesn't even have a standard blaster. She must craft weapons and armor from materials she finds along the way and learn new abilities from the indigenous inhabitants of the planet.

 

[Lichtsang]

Another evil chozo guy cloned the metroids in another planet, or someone from the galactic federation could extract some metroid DNA from Zeres before it was destroyed, or the space pirates have some DNA backup in another place that they could save before the destruction of planet Cebes.

Metroids have been many often cloned in such universe, 3 times already, who cares if they have been cloned for a fourth time, or even fifth.

I think that would undermine the developments in the past. I think the fact that Samus is the last Metroid will be a important plotpoint going forward.