Many and more. Let's give this a shot:
Hollow Knight
Super Mario Bros.
Super Mario Bros. 2 USA
Super Mario Bros. 3
Super Mario World
Final Fantasy
Final Fantasy IV
Final Fantasy VI
Final Fantasy VII
The Legend of Zelda
Zelda II: The Adventure of Link
The Legend of Zelda: A Link to the Past
The Legend of Zelda: Link's Awakening (across all versions)
Super Metroid
Chrono Trigger
Secret of Mana
Super Mario RPG
Contra
Crystalis
EarthBound
Life Force (aka Salamander)
Mega Man 2
Limbo
Infernax
Sonic the Hedgehog
Sonic the Hedgehog 2
Aladdin (Sega Genesis version)
Streets of Rage
Streets of Rage 2
Street Fighter 2
Mortal Kombat
Castlevania II: Simon's Quest
Disney’s Duck Tales
Ninja Gaiden 2: The Dark Sword of Chaos
TMNT: The Arcade Game
Blaster Master (I made it to the last boss like 7-8 times before I finally beat it, so I’m gonna count it)
Probably many more. Between 1988-1998 basically all I did was play video games lol
Roguelikes:
I'm gonna include Binding of Isaac Afterbirth/Repentance on here because I got Dead God, which requires you to beat the game like literally 500 times and took me roughly 1,200 hours to complete.
Also Enter the Gungeon because I got the Platinum.
A better question would be how many games have I beaten 20+ times: Two. Super Metroid and Super Mario Bros. 2 USA. I used to speedrun those games.